Journal: Bioengineering
Article Title: Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness
doi: 10.3390/bioengineering3010005
Figure Lengend Snippet: MVDA of the historical data set. ( A ) removal of outliers prior to analysis; ( B ) PLS-R model fit using two Principal Components, here Comp 1 and 2. R2Y(cum) indicates the explained variance, while Q2(cum) explains the predictive quality using one resp. two principal components; ( C ) VIP plot of the most important variables in the analysis sorted by relevance; ( D ) Loading scatter plot of data relationship between predictors (X) and predicted (Y) variable discriminated by VIP size.
Article Snippet: In order to gather process understanding of how and by which importance the process parameters relate to each other, we used PLS-R (partial least squares regression) in Simca 13.0.3 (Umetrics, Sweden) to analyze the historical dataset.
Techniques: